Selective Antibody Response to Streptococcus gallolyticus Pilus Proteins in Colorectal Cancer Patients
نویسندگان
چکیده
منابع مشابه
Selective antibody response to Streptococcus gallolyticus pilus proteins in colorectal cancer patients.
Streptococcus gallolyticus subsp. gallolyticus (previously called Streptococcus bovis biotype I) infections have long been associated with colorectal cancer (CRC). This work aimed to investigate the CRC-associated humoral immune response to four pilus proteins of this bacterium by newly developed ELISAs. Pilus proteins are interesting diagnostic targets as they are the building blocks of pilin-...
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Streptococcus gallolyticus subsp. gallolyticus Sgg (formerly known as S. bovis type I) is the main causative agent of septicemia and infective endocarditis (IE) in elderly and immunocompromised persons. It belongs to the few opportunistic bacteria, which have been strongly associated to colorectal cancer (CRC). A literature survey covering a period of 40 years (1970–2010) revealed that 65% of p...
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Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong association with colorectal cancer (CRC). This knowledge has important clinical implications, and yet little is known about the role of Sg in the development of CRC. Here we demonstrate that Sg promotes human colon cancer cell proliferation in a manner that depends on cell context, bacterial growth phase an...
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The role, of microbial agents and the infection of the intestinal mucosa in the carcinogenesis, or the development of colorectal cancer (CRC) is one of the hot topics in the field of CRC where much research has been done. However, this topic has long been underestimated by most of the related books. This chapter is intended to cover the relationship of CRC development with bacteria implicated i...
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Colonization by Streptococcus gallolyticus subsp. gallolyticus (SGG) is strongly associated with the occurrence of colorectal cancer (CRC). However, the factors leading to its successful colonization are unknown, and whether SGG influences the oncogenic process or benefits from the tumor-prone environment to prevail remains an open question. Here, we elucidate crucial steps that explain how CRC...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2011
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-11-0321